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The most important new feature of the updated rules is the new format of *Catalytic Activity* predictions. Apart from the EC (*Enzyme Classification*) number and a text describing the activity, the new format contains references to the corresponding Rhea reaction ID (RHEA:16505). Furthermore it contains references to the molecules, which participate in the predicted reaction (e.g. RHEA-COMP:9845, CHEBI:29748). These identifiers allow to find information related to the predicted catalytic activity on [Rhea](https://www.rhea-db.org) and [ChEBI](https://www.ebi.ac.uk/chebi/) website. |