Skip to content
Snippets Groups Projects
Commit 4ba60ebc authored by David Mendez's avatar David Mendez
Browse files

Chemical Probe: start to add mockup page

parent 538279ff
No related branches found
No related tags found
1 merge request!3Add first mockup of the chemical probe report card
<template>
<v-container>
<v-row>
<v-col cols="9">
<h1 class="primary--text">PFI-6: A Chemical Probe for human MLLT1/3</h1>
<v-divider />
<br />
<v-row>
<v-col cols="12">
<h2 class="primary--text">Summary</h2>
</v-col>
</v-row>
<v-row>
<v-col cols="12"> <Summary /> </v-col>
</v-row>
<v-row>
<v-col cols="12">
<h2 class="primary--text">
Chemical Probe & Negative Control Structures and Use
</h2>
</v-col>
</v-row>
<v-row>
<v-col cols="12"> <ControlStructuresAndUse /> </v-col>
</v-row>
</v-col>
<v-col cols="3"> Index </v-col>
</v-row>
</v-container>
</template>
<script>
import Summary from '~/components/report_cards/chemical_probe/Summary.vue'
import ControlStructuresAndUse from '~/components/report_cards/chemical_probe/ControlStructuresAndUse.vue'
export default {
components: {
Summary,
ControlStructuresAndUse,
},
}
</script>
<style></style>
<template>
<v-card>
<v-card-text>
<v-row>
<v-col cols="6">
<v-card tile elevation="0">
<v-card-title>PFI-6 Chemical Probe</v-card-title>
</v-card>
</v-col>
<v-col cols="6">
<v-card tile elevation="0">
<v-card-title>PFI-6N Negative Control</v-card-title>
</v-card>
</v-col>
</v-row>
</v-card-text>
</v-card>
</template>
<script>
export default {}
</script>
<style></style>
<template>
<v-card>
<v-card-subtitle>Overview</v-card-subtitle>
<v-divider />
<v-card-text>
The small YEATS protein domain is found in four human proteins, including
MLLT1 and MLLT3, and is an epigenetic reader of acetyl-lysine histone
marks. MLLT1 has been found to be a driver of acute myeloid leukaemia. A
collaboration between Pfizer and the SGC has resulted in the discovery of
PFI-6, a potent disrupter of protein:protein interactions involving the
YEATS domains of MLLT1/3.
</v-card-text>
<v-divider />
<v-card-subtitle>Details</v-card-subtitle>
<v-divider />
<v-card-text>
<v-row class="details-row" dense>
<v-col cols="12">
<b>Chemical Probe Name:</b>
PFI-6
</v-col>
</v-row>
<v-divider />
<v-row class="details-row" dense>
<v-col cols="12">
<b>Negative control compound:</b>
PFI-6N
</v-col>
</v-row>
<v-divider />
<v-row class="details-row" dense>
<v-col cols="12">
<b>Target(s) (synonyms):</b>
MLLT1/MLLT3 (ENL;LTG19;YEATS1 / AF- 9;YEATS3)
</v-col>
</v-row>
<v-divider />
<v-row class="details-row" dense>
<v-col cols="12">
<b>Recommended in vitro assay concentration:</b>
<p>
10 µM for PFI-6 and PFI-6N; use with negative control and orthogonal
probe for best interpretation of data
</p>
</v-col>
</v-row>
<v-divider />
<v-row class="details-row" dense>
<v-col cols="12">
<b>Web link for more details:</b>
<a href="https://www.thesgc.org/chemical-probes/PFI-6" target="_blank"
>https://www.thesgc.org/chemical-probes/PFI-6</a
>
</v-col>
</v-row>
<v-divider />
<v-row class="details-row" dense>
<v-col cols="12">
<b>Protein Target Classification:</b>
<br />
<br />
<p>
<v-chip outlined color="secondary" label>
Unclassified protein
</v-chip>
>
<v-chip outlined color="secondary" label>
Epigenetic regulator
</v-chip>
>
<v-chip outlined color="secondary" label> Reader </v-chip>
>
<v-chip outlined color="secondary" label> Bromodomain </v-chip>
</p>
</v-col>
</v-row>
<v-divider />
<v-row class="details-row" dense>
<v-col cols="12">
<b>Publications:</b>
None at the time of writing
</v-col>
</v-row>
<v-divider />
<v-row class="details-row" dense>
<v-col cols="12">
<b>Orthogonal chemical probes:</b>
NVS-MLLT-1
</v-col>
</v-row>
<v-divider />
<v-row class="details-row" dense>
<v-col cols="12">
<b>Cellular assay(s) for target-engagement:</b>
NanoBRET FRAP
</v-col>
</v-row>
<v-divider />
<v-row class="details-row" dense>
<v-col cols="12">
<b>Suitable for in vivo use:</b>
no
</v-col>
</v-row>
<v-divider />
</v-card-text>
<v-card-actions>
<v-btn
href="https://drive.google.com/file/d/1FQOGQxTdcIfTeM1Vq73vbHOEJ0ZptkHV/view?usp=sharing"
color="primary"
>
<v-icon>mdi-download</v-icon> PDF
</v-btn>
</v-card-actions>
</v-card>
</template>
<script>
export default {}
</script>
<style>
.details-row {
margin: 0;
}
</style>
<template>
<div><ChemicalProbeReportCard /></div>
</template>
<script>
import ChemicalProbeReportCard from '~/components/report_cards/chemical_probe/ChemicalProbeReportCard.vue'
export default {
components: {
ChemicalProbeReportCard,
},
}
</script>
<style></style>
0% or .
You are about to add 0 people to the discussion. Proceed with caution.
Finish editing this message first!
Please register or to comment